Genetics of surface antigen expression in Pneumocystis carinii.
نویسندگان
چکیده
This article reviews the molecular genetic data pertaining to the major surface glycoprotein (MSG) gene family of Pneumocystis carinii and its role in surface variation and compares this fungal system to antigenic variation systems in the protozoan Trypanosoma brucei and the bacteria Borrelia spp.
منابع مشابه
Use Of Razi Bovine Kidney Cell Line For Proliferation Of Pneumocystis Carinii
Background and Objective: Pneumocystis pneumonia (PCP) has been historically the most prevalent opportunisticinfection in patients infected with the human immunodeficiencyvirus. Culture of the organism has not been faced with suitable success in artificial media, while various results have been reported for cell culture media. The aim of this study was proliferation of Pneumocystis carin...
متن کاملCharacterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region.
To facilitate studies of Pneumocystis carinii infection in humans, we undertook to better characterize and to express the major surface glycoprotein (MSG) of human P. carinii, an important protein in host-pathogen interactions. Seven MSG genes were cloned from a single isolate by PCR or genomic library screening and were sequenced. The predicted proteins, like rat MSGs, were closely related but...
متن کاملIntroduction of a Case of Interstitial Pneumonia Related to Pneumocystis Carinii
This article has no abstract.
متن کاملSurfactant protein D interacts with Pneumocystis carinii and mediates organism adherence to alveolar macrophages.
Pneumocystis carinii interacts with glycoproteins present in the lower respiratory tract through its mannose-rich surface antigen complex termed gpA. Surfactant protein D (SP-D) is a recently described component of the airspace lining material that possesses a calcium-dependent lectin domain capable of interacting with glycoconjugates present on microorganisms and leukocytes. Accordingly, we ev...
متن کاملFunctional glycosylphosphatidylinositol anchor signal sequences in the Pneumocystis carinii PRT1 protease family.
Pneumocystis carinii is fungus which is a frequent cause of severe pneumonia in immunocompromised individuals. The P. carinii genome contains the PRT1 subtelomeric multigene family that encodes a kexin-like serine protease which is expressed on the surface of P. carinii. Analysis of the sequence of the carboxy-terminal sequence of many copies of PRT1 showed that they contained motifs characteri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Infection and immunity
دوره 69 2 شماره
صفحات -
تاریخ انتشار 2001